ОЦІНКА АСОЦІАЦІЙ ПОЛІМОРФІЗМІВ ГЕНІВ MTHFR C677T, MTR A2756G, MTHFR A1298C ІЗ РОЗВИТКОМ ДІАБЕТИЧНОЇ РЕТИНОПАТІЇ У ПАЦІЄНТІВ НА ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ
نویسندگان
چکیده
Вступ.Активно вивчається зв'язок поліморфізмів генів, що кодують синтез ферментів і кофакторів, пов'язаних з метаболізмом гомоцистеїну, із розвитком мікросудинних ускладнень на тлі цукрового діабету 2 типу (ЦД2). В світі існує невизначеність відносно ризику розвитку діабетичної ретинопатії (ДР) у носіїв різних поліморфізмів.
منابع مشابه
Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency
Folate deficiency is strongly associated with cardiovascular disease. We aimed to explore the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, and methionine synthase reductase (MTRR) A66G polymorphisms on folate deficiency in a Chinese hypertensive population. A total of 480 subjects aged 28-75 were enrolled in this study from ...
متن کاملRole of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility
BACKGROUND Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF. METHODOLOGIES 456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756...
متن کاملRole of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development.
Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087)...
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Objective: Neural tube defect (NTD) incidence could be effectively reduced by folic acid supplementation before and during pregnancy. We studied single nucleotide polymorphisms (SNPs) involved in folate metabolism to explore genetic susceptibility to NTD. We studied the association between 12 SNPs involved in 11 folate metabolism genes and NTDs. Methods: We enrolled 76 children with NTD and 188...
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In this study, it was aimed to determine the allele frequencies and genotype distributions of MTHFR gene C677T and A1298C polymorphisms in a Turkish study population with polycystic ovary syndrome. Genomic DNA was isolated from blood samples of 30 patients with polycystic ovary syndrome and 28 healthy controls. PCR-RFLP technique was used to analyze MTHFR gene C677T and A1298C polymorphisms. Pr...
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ژورنال
عنوان ژورنال: Grail of science
سال: 2022
ISSN: ['2710-3056']
DOI: https://doi.org/10.36074/grail-of-science.22.07.2022.079